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Description
Approved 20 years ago as a treatment for diabetes, GLP 1 drugs have been found also to help patients significantly reduce weight. More than 30 million people in the U.S. have had their Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP 1 GIP GCG receptor triagonist: Cell Metabolism Eli Lilly slashes prices of low doses of weight loss drug by scrapping auto injector LLY Becomes "Dominant" GLP 1 Winner, NVO Growth Turns Anemic Current Insights, Advantages and Challenges of Small Molecule Glucagon like Peptide 1 Receptor Agonists: A Scoping Review Published in Journal of Brown Hospital Medicine
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.2 ★★★★★
Based on 589 reviews
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Product Reviews
★★★★★ 5
4 Paws up! My dogs LOVE them
Flavor Name: Variety Packs, Size: 3 Pack, Set name: Large, Flavor Name: Variety Packs, Size: 3 Pack, Set name: Large
I have 2 large dogs who LOVE THESE.
A Great Pyrenees mix who’s a skinny 80lbs and a lab/terrier mix who’s a chunky 50lbs. They both love bones and can REALLY chew through them quickly so I’m really picky about what I buy them.
Here is what is important to me and how I rate and choose bones. These are my comments on this bone set specifically:
Do they break/splinter?
-They don’t splinter, I have seen smaller pieces that have broken off and when the bone gets down to the end (but this is normal with bones) at which point those pieces can be thrown away. I have never had an issue with them choking, being too small or hurting my dogs though and they are aggressive chewers so I could see this happening with some dogs and never happening with others. 4/5 stars for this.
Do they smell/leave stains on the carpet?
-Nope! No odor and they actually leave my dogs breath smelling better and their teeth cleaner! 5/5 stars
Does it upset my dog’s stomach? (My bigger guy can’t tolerate a LOT of things, he vomits often and also gets diarrhea if he eats the “wrong” thing so I have to be very cautious.)
-NOT at all! No upset tummies. This is always very, very important to me. Make sure you have lots of water nearby for your pups though, these will make them very thirsty. 5/5 stars
Do they hurt my dogs tongue, mouth or teeth?
-Nope, no issues with this. They’re able to gnaw into these aggressively without hurting themselves. 5/5 stars
Are they gone in 2 seconds?
-No! I’m always worried the “stuffed” bones will be left in the dust after the stuffing is all gone but my dogs will still keep chewing on these after the stuffing is gone. They still enjoy the bones and they last for quite some time, weeks at minimum. I can also stick some peanut butter or other treats back in the middle after they get the original stuffing all out of them to “reuse” them if it seems like they’re getting a little bored with them. 5/5 stars
Do my dogs ACTUALLY LIKE THEM?
-They love them. 5/5 stars
Price?
-Great and totally affordable. $20 for 3 of them.. so less than $7/bone. This is comparable to a bone from the pet store and these last a lot longer than something you would find there in the “fresh” grocery-store-like-section of the pet stores.
I’m an avid review reader, especially when it comes to items for my fur babies because I want the best for them. I truly love these bones and will keep buying them.
I will continue to buy these!
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Reviewed in the United States on August 26, 2019
★★★★★ 4
⭐️⭐️⭐️⭐️ Finally Found a Long-Lasting Bone That Actually Keeps My Dog Busy
Flavor Name: Variety Packs, Size: 3 Pack, Set name: Large
I’ve tried a lot of filled bones and chew treats over the years, and most fall into two categories: gone in 5 minutes, or upset stomach later. These filled beef shank bones hit the sweet spot.
The bone itself is thick, dense, and real, not a thin, brittle shell. My medium-large dog is an aggressive chewer, and this keeps him occupied for a solid 30–45 minutes working on the filling, then even longer gnawing on the bone afterward.
The filling smells fresh and appetizing (not rancid or overly greasy), and my dog goes crazy for it. We’ve tried the cheese-style and peanut butter–style fillings, and both were a big hit. No crumbly mess, no weird residue, and no digestive issues so far.
What I really appreciate is that these feel safer than many cheaper alternatives. The edges don’t splinter, and the bone wears down gradually instead of cracking.
Why I’ll keep buying these:
• Long-lasting even for power chewers
• Real beef shank bone, not pressed junk
• Filling dogs actually care about
• Helps with boredom and anxiety
• Good value compared to pet store brands
Minor cons:
• Can get a little smelly after heavy chewing
• I supervise and take it away when it gets small (as with any bone)
If you’re tired of wasting money on chews that disappear in minutes, these are a fantastic upgrade. My dog is obsessed, and I finally feel good about what I’m giving him.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 5, 2026
★★★★★ 5
Best bones out there
Flavor Name: Variety Packs, Size: 3 Pack, Set name: Large
These are the best bones I’ve ever bought. I have a lab puppy and as you can imagine most bones don’t last long around here, but this one keeps him entertained for days.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 4, 2026
★★★★★ 5
Happy doggy dancing my ensue
Flavor Name: Variety Packs, Size: 1.26 Pound (Pack of 1), Set name: Small
I haven’t tried them, but the dogs seem to like them. They do that tippy tappy happy dance when these come out.
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Reviewed in the United States on April 26, 2026
★★★★★ 3
Sturdy
Flavor Name: Variety Packs, Size: 3 Pack, Set name: Large, Flavor Name: Variety Packs, Size: 3 Pack, Set name: Large
Ok so I'm very happy that my standard poodle seemed to really enjoy this product. She was lacking and biting it for hours and days. That said she has still yet to make a dent in the bone. It seems to be too hard and too thick for her. I was surprised how heavy it was! It is large enough it is completely safe to leave her in the other room with. No strange odor or transfer of color. I'd say for the cost it isn't worth it as she is only getting filling and not able to eat the bone for some reason. Then again she is entertained for hours..so maybe so. Doesn't seem to bother her sensitive tummies either.
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Reviewed in the United States on May 7, 2026
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